For decades, researchers have been searching for the reason immune cells, which would normally keep inflammation at bay, can’t seem to do their job in SLE patients—but to no avail.
However, a team of scientists from the University College London have now published a study suggesting that in SLE patients, the B cells used to normally regulate inflammation are getting signaled to become pro-inflammatory cells instead.
Findings from this new study prove that the miscommunication in lupus patients seems to come from an imbalance of three types of immune cells:
1) B cells that produce antibodies to protect the body against foreign microbes (and a primary driver of autoimmune disorders),
3) Regulatory B cells that suppress excessive immune responses, which are severely lacking in lupus patients.
Claudia Mauri, Ph.D., the senior study author and professor of immunology at the University College London concluded that:
“This would be an important step towards personalized medicine for the treatment of lupus.”
AND I AGREE!